Molecular Mechanisms of Cellular Cholesterol Efflux

O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma

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A Possible Mechanism of Cellular Cholesterol Efflux*

After in vitro incubation with radiolabeled amino acids, extracts of various chicken tissues were reacted with antiserum against apolipoprotein AI (apo-AI) of plasma high density lipoprotein. Radiolabeled apo-AI was found in liver and intestine as well as in the kidney and a variety of peripheral tissues including aorta, peripheral arteries, veins, and skeletal muscle. The immunoreactive apo-AI...

Regulation and mechanisms of macrophage cholesterol efflux.

Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux.

ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and HDL metabolism. ABCA1 mediates cellular cholesterol and phospholipid efflux to lipid-poor apolipoproteins, and upregulation of ABCA1 activity is antiatherogenic. ApoA-I, the major apolipoprotein component of HDL, promotes ABCA1-mediated cholesterol and phospholipid efflux, probably by directly binding ...

Importance of different pathways of cellular cholesterol efflux.

The removal of excess free cholesterol from cells by HDL or its apolipoproteins is important for maintaining cellular cholesterol homeostasis. This process is most likely compromised in the atherosclerotic lesion because the development of atherosclerosis is associated with low HDL cholesterol. Multiple mechanisms for efflux of cell cholesterol exist. Efflux of free cholesterol via aqueous diff...